Fatal infection with influenza A (H5N1) virus in China.

n engl j med 354;25 www.nejm.org june 22, 2006 2731 paraganglioma syndrome 1; in the extent of multifocal tumors in the group with MEN-2, the group with von Hippel–Lindau disease, and the group with paraganglioma syndrome 1; and in the extent of extraadrenal tumors in the group with MEN-2, the group with von Hippel–Lindau disease, the group with paraganglioma syndrome 1, and the group with paraganglioma syndrome 4. Patients with neurofibromatosis type 1 had a relatively high (but not significant) prevalence of malignant disease (12 percent), second only to that among patients with paraganglioma syndrome 4 who had a germ-line mutation in the SDHB gene (24 percent). Taken together, 33 percent of all symptomatic patients with pheochromocytoma in the registry carried germ-line mutations in one of the five genes, including NF1. Dr. Neumann is supported by a grant (NE 571/5-3) from the Deutsche Forschungsgemeinschaft, a grant (70-3313-ne1) from the Deutsche Krebshilfe, and a grant (LSHC-CT-2005-518200) from the European Union. Birke Bausch, M.D. Wiktor Borozdin, Ph.D. Hartmut P.H. Neumann, M.D.